The Healthspan Map · Body system

Reproductive & Developmental

Conditions in this system

Named for a condition in this system

Evidence naming a condition in Reproductive & Developmental — 52 sources.In the order the Map holds them: strongest evidence first. That is a statement about the evidence, not about what matters most.
Nutrient or leverDirectionStrengthEvidence typeWhat was foundSource
Cardio (moderate + intervals)Do thisStrongRCT / trialA 3-month program of 150 min/week moderate aerobic activity improved erectile function (IIEF 11.0→16.5 vs negligible in controls) by restoring endothelial integrity.Physical activity & erectile function (Transl Androl Urol, PMC4837314) (opens in a new tab)
Tobacco / vaping — quitDo thisStrongEstablished clinicalSmoking is a major modifiable cause of erectile dysfunction and impairs sperm count, motility and DNA integrity, with broad fertility harms in both sexes.Lifestyle modification & erectile dysfunction (PMC4291878) (opens in a new tab)
Tobacco / vaping — quitDo thisStrongEstablished clinicalSmoking is a major modifiable cause of erectile dysfunction and impairs sperm count, motility and DNA integrity, with broad fertility harms in both sexes.US Surgeon General — The Health Consequences of Smoking (opens in a new tab)
ZincEat enough ofStrongRCT / meta-analysisZinc is critical for sperm production and testosterone; in asthenospermic men, zinc supplementation increased sperm volume, motility and total count.Impact of food & nutraceuticals on fertility (ScienceDirect 2025) (opens in a new tab)
Added SugarsDon't overdoModerateReview / narrativeHigh glycemic load and sugary intake raise insulin/androgens and are associated with ovulatory infertility, PCOS and lower fertility potential.Female infertility & diet (Frontiers Nutr 2022) (opens in a new tab)
Alcohol — cut backDo thisModerateCohort / observationalExcessive alcohol contributes to erectile dysfunction, lowers testosterone and impairs sperm and female fertility.Lifestyle modification & erectile dysfunction (PMC4291878) (opens in a new tab)
Anchor foodsWatch thisModerateReview / narrativeGreater Mediterranean-diet adherence is associated with lower ED prevalence and better fertility in both sexes, sperm quality and IVF outcomes, via endothelial and hormonal health.Dietary factors, Mediterranean diet & ED (ScienceDirect) (opens in a new tab)
BMIWatch thisModerateCohort / observationalObesity lowers testosterone and nitric-oxide availability (→ ED) and drives PCOS/anovulation and poor sperm; underweight causes amenorrhea — U-shaped, and losing 5-10% of weight can restore ovulation.Lifestyle modification & erectile dysfunction review (PMC4291878) (opens in a new tab)
Blood pressureWatch thisModerateReview / narrativeErectile dysfunction is fundamentally vascular; hypertension/endothelial dysfunction (and some antihypertensives) impair erections, and BP control is part of ED care.Dietary factors, Mediterranean diet & ED (ScienceDirect) (opens in a new tab)
Cardio / VO2maxWatch thisModerateRCT / trialHigher aerobic fitness supports the endothelial function behind erections and healthy testosterone; very excessive endurance can lower testosterone (J-curve).Physical activity & erectile function (PMC4837314) (opens in a new tab)
Colours a dayWatch thisModerateReview / narrativeAntioxidant-rich fruits and vegetables (vitamin C, lycopene, carotenoids) are associated with higher sperm count/motility by limiting oxidative damage.Diet & male infertility (PMC7291266) (opens in a new tab)
Daily movement baselineDo thisModerateRCT / trialRegular activity and less sitting support erectile/endothelial function and fertility; sedentary living worsens both.Physical activity & erectile function (PMC4837314) (opens in a new tab)
EPA/DHA (omega-3)Eat enough ofModerateReview / narrativeOmega-3s from fish or nuts support sperm-membrane structure and spermatogenesis and relate to better embryo quality in women.Diet & men’s fertility (Fertil Steril 2018) (opens in a new tab)
Folate (B9)Eat enough ofModerateCohort / observationalFolate supports ovulation, embryo quality and IVF success and (with zinc/B12 in one-carbon metabolism) spermatogenesis; preconception folate is standard for neural-tube prevention.Female fertility nutrition review (PMC8634384) (opens in a new tab)
Hot food in plastic — avoidDo thisModerateCohort / observationalHeating food in plastic leaches endocrine-disrupting BPA and phthalates that lower sperm quality and disrupt the hypothalamic-pituitary-gonadal axis; glass/steel are safer.Endocrine-disrupting chemicals & male fertility (Frontiers 2023) (opens in a new tab)
IronEat enough ofModerateCohort / observationalHigher iron intake from plants and supplements was part of the "fertility diet" linked to markedly lower ovulatory-disorder infertility.Diet & ovulatory-disorder infertility (Chavarro, NHS-II) (opens in a new tab)
Movement (breaking up sitting)Do thisModerateReview / narrativeProlonged sitting raises scrotal temperature and, with inactivity, is linked to reduced sperm quality; breaking up sitting helps.Diet & male infertility (PMC7291266) (opens in a new tab)
SeleniumEat enough ofModerateReview / narrativeSelenium is built into sperm selenoproteins; adequate status supports sperm motility and guards against oxidative sperm damage.Diet & male infertility (PMC7291266) (opens in a new tab)
Sleep durationWatch thisModerateCohort / observationalOne week of 5-hour nights cut daytime testosterone ~10-15% in healthy young men; short sleep also reduces fecundability, with fertility U-shaped to sleep duration.Sleep restriction & testosterone (PMC6917985) (opens in a new tab)
Sleep quality (refreshed)Watch thisModerateCohort / observationalFragmented sleep and obstructive sleep apnea are independently associated with lower testosterone, impaired semen quality and erectile dysfunction that improves when OSA is treated.OSA & male reproductive function (PMC12483905) (opens in a new tab)
Strength (resistance)Do thisModerateCohort / observationalResistance training acutely raises testosterone and supports the muscle mass and metabolic health tied to reproductive hormones.Sleep restriction & testosterone (PMC6917985) (opens in a new tab)
Sugary drinks & snacks — cut backDo thisModerateReview / narrativeHigh glycemic load and sugary intake raise ovulatory-infertility and PCOS risk (insulin/androgen effects) and are linked to poorer sperm quality.Female infertility & diet (Frontiers Nutr 2022) (opens in a new tab)
Supplement disciplineDo thisModerateReview / narrativeCorrecting deficiencies (folate, zinc, vitamin D, omega-3) supports fertility, but antioxidant megadosing can backfire via reductive stress — sensible, food-first dosing matters.Dietary antioxidants & male infertility – antioxidant paradox (PMC8003818) (opens in a new tab)
Trans fatDon't overdoModerateCohort / observationalIncreasing trans-fat intake by even 2% of energy significantly raised ovulatory-disorder infertility risk, and trans/saturated fats relate to poorer sperm quality.Female fertility nutrition review (PMC8634384) (opens in a new tab)
Ultra-processed food — cut backDo thisModerateReview / narrativeWestern/ultra-processed diets high in trans/saturated fat, processed meat and refined sugar are linked to reduced sperm quality and hormonal imbalance.Diet & male infertility (PMC7291266) (opens in a new tab)
Vitamin A (RAE)Eat enough ofModerateMechanisticRetinoic acid from vitamin A is essential for spermatogenesis; deficiency halts sperm production and higher serum retinol tracks with normal sperm parameters.Nutrition & male fertility (Transl Androl Urol 2020) (opens in a new tab)
Vitamin A (RAE)Don't overdoModerateEstablished clinicalHigh-dose vitamin A is teratogenic (>10,000 IU/day risk in pregnancy; isotretinoin is a potent teratogen), and chronic excess also impairs sperm production, morphology and motility.Vitamin A-mediated birth defects review (PMC10788247) (opens in a new tab)
Vitamin CEat enough ofModerateReview / narrativeVitamin C is the principal antioxidant in seminal plasma; adequate intake protects sperm from reactive-oxygen-species damage and recycles vitamin E.Diet & men’s fertility (Fertil Steril 2018) (opens in a new tab)
Vitamin DEat enough ofModerateSystematic reviewVitamin D is positively associated with semen quality and androgen status in men and with IVF outcomes and PCOS management in women.Vitamin D & fertility systematic review (PubMed 22275473) (opens in a new tab)
Vitamin EEat enough ofModerateReview / narrativeVitamin E neutralises reactive oxygen species in sperm plasma membranes; with vitamin C it reduces sperm DNA damage.Diet & men’s fertility (Fertil Steril 2018) (opens in a new tab)
Waist-to-height ratioWatch thisModerateCohort / observationalWaist-based central-adiposity measures track reduced fertility beyond BMI alone.Nutritional status & female infertility case-control (PMC11496271) (opens in a new tab)
Waist-to-hip ratioWatch thisModerateCohort / observationalCentral/abdominal adiposity predicts reduced fertility partly independent of BMI, via insulin resistance and hormonal disruption.Nutritional status & female infertility case-control (PMC11496271) (opens in a new tab)
Body Roundness IndexWatch thisEmergingCohort / observationalCentral-adiposity indices flag the fat distribution linked to hormonal and ovulatory disruption.Nutritional status & female infertility case-control (PMC11496271) (opens in a new tab)
CalciumEat enough ofEmergingSystematic reviewCalcium signalling (supported by vitamin D) contributes to sperm motility and capacitation.Vitamin D & fertility systematic review (PubMed 22275473) (opens in a new tab)
Calm rest spaceDo thisEmergingCohort / observationalChronic stress raises cortisol, which suppresses GnRH and reproductive-hormone output and dampens libido and sexual function.Sleep restriction & testosterone (PMC6917985) (opens in a new tab)
Carotenoids (provitamin A)Eat enough ofEmergingReview / narrativeDietary beta-carotene has been associated with lower sperm chromosomal aneuploidy and provides antioxidant/provitamin-A support.Diet & men’s fertility (Fertil Steril 2018) (opens in a new tab)
Cook real foodDo thisEmergingReview / narrativeHome-cooked whole-food meals underpin the Mediterranean/fertility pattern and reduce ultra-processed and packaging-related exposures.Diet & male infertility (PMC7291266) (opens in a new tab)
Falling & staying asleepWatch thisEmergingCohort / observationalSleep continuity underpins the nocturnal testosterone surge; fragmented sleep blunts it.Sleep restriction & testosterone (PMC6917985) (opens in a new tab)
Indoor air qualityDo thisEmergingCohort / observationalAir pollution and airborne pollutants are among the environmental exposures associated with reduced sperm quality and fertility.Endocrine-disrupting chemicals & male fertility (Frontiers 2023) (opens in a new tab)
IronDon't overdoEmergingReview / narrativeExcess iron generates oxidative stress in seminal plasma that can damage sperm; iron overload is unfavourable to reproductive cells.Diet & male infertility (PMC7291266) (opens in a new tab)
Loneliness — reduceWatch thisEmergingReview / narrativeIsolation, depression and low mood are associated with reduced sexual desire and function; connection and mood support sexual health.Lifestyle modification & erectile dysfunction (PMC4291878) (opens in a new tab)
Morning daylightDo thisEmergingSystematic reviewDaylight supports vitamin D synthesis and circadian regulation of reproductive hormones.Vitamin D & fertility systematic review (PubMed 22275473) (opens in a new tab)
ProteinEat enough ofEmergingCohort / observationalAdequate energy/protein maintains reproductive function; chronic under-fuelling suppresses ovulation (though excess animal protein links to more ovulatory infertility than plant protein).Female fertility nutrition review (PMC8634384) (opens in a new tab)
Saturated fatDon't overdoEmergingReview / narrativeDiets high in saturated fat are associated with reduced sperm concentration and quality.Diet & male infertility (PMC7291266) (opens in a new tab)
Screens before bed — cut backDo thisEmergingReview / narrativeLate-night screens disrupt the sleep/circadian rhythm that governs testosterone, and laptops on the lap add scrotal heat that can impair sperm.Sleep & men’s health (PMC7108988) (opens in a new tab)
SeleniumDon't overdoEmergingReview / narrativeSelenium is essential for sperm but has a narrow window; excess (selenosis) can reduce sperm quality.Dietary antioxidants & male infertility – antioxidant paradox (PMC8003818) (opens in a new tab)
Sleep regularityWatch thisEmergingReview / narrativeCircadian regularity supports the hypothalamic-pituitary-gonadal rhythm; disrupted schedules relate to poorer reproductive-hormone profiles.Sleep & men’s health (PMC7108988) (opens in a new tab)
Vitamin B12Eat enough ofEmergingReview / narrativeVitamin B12, via one-carbon metabolism with folate, supports spermatogenesis and sperm DNA integrity.Diet & men’s fertility (Fertil Steril 2018) (opens in a new tab)
Vitamin CDon't overdoEmergingReview / narrativeMegadosing antioxidants such as vitamin C can create reductive stress detrimental to sperm function — more is not better.Dietary antioxidants & male infertility – antioxidant paradox (PMC8003818) (opens in a new tab)
Vitamin EDon't overdoEmergingReview / narrativeExcess antioxidant supplementation including vitamin E may disturb the redox balance sperm need, potentially harming function.Dietary antioxidants & male infertility – antioxidant paradox (PMC8003818) (opens in a new tab)
Warmth & quality of tiesWatch thisEmergingReview / narrativeRelationship quality and psychological wellbeing strongly shape sexual desire and function alongside the physical drivers of ED.Lifestyle modification & erectile dysfunction (PMC4291878) (opens in a new tab)
ZincDon't overdoEmergingReview / narrativeExcess zinc can induce copper deficiency and, as antioxidant over-supplementation, may impair rather than help sperm function.Dietary antioxidants & male infertility – antioxidant paradox (PMC8003818) (opens in a new tab)

Held for the whole system

Evidence held for Reproductive & Developmental as a whole — 11 sources.In the order the Map holds them: strongest evidence first. That is a statement about the evidence, not about what matters most.
Nutrient or leverDirectionStrengthEvidence typeWhat was foundSource
Folate (B9)Eat enough ofStrongRCT / meta-analysisLow periconceptional folate causes fetal neural tube defects (spina bifida, anencephaly) and raises preterm birth, growth restriction and miscarriage risk.NIH ODS / USPSTF – Folate (opens in a new tab)
Folate (B9)Eat enough ofStrongRCT / meta-analysisLow periconceptional folate causes fetal neural tube defects (spina bifida, anencephaly) and raises preterm birth, growth restriction and miscarriage risk.Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis, Nutr J 2012 (opens in a new tab)
IodineEat enough ofStrongEstablished clinicalSevere deficiency in pregnancy causes cretinism (irreversible physical/neurological impairment), miscarriage, stillbirth and neonatal hypothyroidism — the world's leading preventable cause of brain damage.Severe-iodine-deficiency-in-pregnancy review (opens in a new tab)
Vitamin A (RAE)Don't overdoStrongEstablished clinicalPreformed vitamin A is a potent teratogen; excess in pregnancy causes severe fetal malformations.StatPearls – Vitamin A Toxicity (opens in a new tab)
ZincEat enough ofStrongEstablished clinicalDeficiency causes growth retardation, delayed sexual maturation and, in pregnancy, preterm birth and low birth weight.NIH ODS – Zinc (opens in a new tab)
CalciumDon't overdoModerateCohort / observationalHigher calcium intake may increase prostate cancer risk. (Cancer folded into system.)NIH ODS – Calcium (opens in a new tab)
CholineEat enough ofModerateEstablished clinicalCholine is important in pregnancy for fetal brain and neural-tube development; prenatal supplements often lack it.NIH ODS / Harvard – Choline (opens in a new tab)
CholineEat enough ofModerateEstablished clinicalCholine is important in pregnancy for fetal brain and neural-tube development; prenatal supplements often lack it.NIH Office of Dietary Supplements — Choline (opens in a new tab)
SeleniumEat enough ofModerateCohort / observationalSelenium is needed for sperm formation; deficiency is linked to male infertility.NIH ODS – Selenium (opens in a new tab)
Vitamin A (RAE)Eat enough ofModerateMechanisticVitamin A is required for normal growth, reproduction and fetal development; deficiency impairs growth in children.NIH ODS – Vitamin A & Carotenoids (opens in a new tab)
Vitamin EDon't overdoModerateRCT / meta-analysisThe SELECT trial found high-dose vitamin E supplements significantly increased prostate cancer risk. (Cancer folded into system.)NIH ODS – Vitamin E (SELECT trial) (opens in a new tab)