| Folate (B9) | Eat enough of | ●●●Strong | Established clinical | Folate deficiency is one of the two most common causes of megaloblastic anemia. | Megaloblastic anemia (B12/folate) (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | RCT / meta-analysis | B-vitamin supplementation aids stress/anxiety regulation; supports neurotransmitter synthesis. | Young et al. 2019, Nutrients (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Cohort / observational | Low folate (especially with low B12) is associated with cognitive decline and higher Alzheimer risk. | Linus Pauling Institute; Huskisson et al. 2007 (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Review / narrative | Low folate (especially with low B12) is associated with cognitive decline and higher Alzheimer risk. | Linus Pauling Institute — Folate (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Review / narrative | Folate supports DNA synthesis and red-cell formation; deficiency contributes to fatigue and anaemia. | Micronutrients for energy/fatigue review (Tardy 2020) (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Established clinical | Deficiency causes neuropsychiatric symptoms including depression and cognitive impairment. | StatPearls – Folate (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | Cohort / observational | Higher dietary folate intake is inversely associated with migraine frequency; evidence emerging. | Dietary B6/folate-migraine association (via food-migraine review 2024) (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Cohort / observational | Folate supports serotonin/melatonin formation; low folate intake is associated with short sleep. | Peuhkuri 2012; NHANES 2005-2016 (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Review / narrative | Folate supports serotonin/melatonin formation; low folate intake is associated with short sleep. | Peuhkuri et al., "Diet promotes sleep duration and quality", Nutr Res 2012 (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | Review / narrative | Folate deficiency contributes to peripheral neuropathy through the homocysteine/B-vitamin pathway. | Nutritional & toxic neuropathy (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Cohort / observational | Folate supports ovulation, embryo quality and IVF success and (with zinc/B12 in one-carbon metabolism) spermatogenesis; preconception folate is standard for neural-tube prevention. | Female fertility nutrition review (PMC8634384) (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | Review / narrative | Folate deficiency causes cheilitis, hair depigmentation and mucocutaneous hyperpigmentation. | Folate & skin (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | RCT / meta-analysis | B-vitamin supplementation (>=3 B-group incl. B6/B12/folate) produces a small but significant reduction in stress (SMD 0.23). | Young et al. 2019, Nutrients (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | Review / narrative | Folate supports nerve health and circulation relevant to the auditory system - emerging. | Diet & tinnitus (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●Emerging | Review / narrative | B-vitamin deficiency (folate/B12/B6) raises homocysteine, associated with AMD; folate supports optic-nerve/retinal health. | Retinal/ocular supplements review (PMC9710404) (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Review / narrative | Folate is required for immune-cell proliferation and the Th1 response. | Folate & lymphocytes (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●●Strong | RCT / meta-analysis | Low periconceptional folate causes fetal neural tube defects (spina bifida, anencephaly) and raises preterm birth, growth restriction and miscarriage risk. | NIH ODS / USPSTF – Folate (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●●Strong | RCT / meta-analysis | Low periconceptional folate causes fetal neural tube defects (spina bifida, anencephaly) and raises preterm birth, growth restriction and miscarriage risk. | Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis, Nutr J 2012 (opens in a new tab) |
|---|
| Folate (B9) | Eat enough of | ●●Moderate | Cohort / observational | Deficiency raises homocysteine, contributing to vascular endothelial dysfunction and cardiovascular/stroke risk. | StatPearls – Folate (opens in a new tab) |
|---|